Metabolic profiling and antibacterial activity of Eryngium pristis Cham. & Schltdl. - prospecting for its use in the treatment of bacterial infections

Morbidity and mortality of the infected patients by multidrug-resistant bacteria have increased, emphasizing urgency fight for discovery new innovative antibiotics. In this sense, natural products emerge as valuable sources bioactive compounds. Among biodiversity, Eryngium pristis Cham. & Schltdl. (Apiaceae Lindl.) is traditionally used to treat thrush ulcers throat mouth, diuretic emmenagogue, but scarcely known an antimicrobial agent. With context in mind, goals study were investigate metabolic profile antibacterial activity ethanolic extract (EE-Ep) hexane (HF-Ep), dichloromethane (DF-Ep), ethyl acetate (EAF-Ep) butanol (BF-Ep) fractions from E. leaves. Gas Chromatography-Mass Spectrometry (GC-MS) was performed stablish revealed presence 12 14 compounds EAF-Ep HF-Ep, respectively. β-selinene, spathulenol, globulol, 2-methoxy-4-vinylphenol, α-amyrin, β-amyrin, lupeol derivative some phytochemicals identified. The determined Minimal Inhibitory Concentration (MIC) using broth micro-dilution against eight ATCC® five methicillin-resistant Staphylococcus aureus (MRSA) clinical strains. HF-Ep most effective (MIC ≤ 5,000 µg/µL), being active largest part tested Gram-positive Gram-negative bacterial strains, including MRSA, with exception Escherichia coli (ATCC 25922) Pseudomonas aeruginosa 9027) 27853). These results suggest that a source search antibiotics which can be interesting therapeutic approach recover mainly MRSA